San Francisco 49ers vs. Philadelphia Eagles
Line: San Francisco -7
Where: Levi’s Stadium
When: Sunday, 10/4, at 8:20 p.m. ET
Philadelphia has been one of the most disappointing teams in the NFL through the first three
games of the season.
The Eagles are 0-2-1 and have failed to cover the spread in all three games. They will be hoping
to spring an upset as 7-point underdogs against an injury-riddled San Francisco team on Sunday
The line opened with the 49ers as 6-point favorites, but it has moved a full point throughout the
week. Sunday’s total opened at 47.5 before moving to 45, but it has ticked back up to 46 as of
Philadelphia quarterback Carson Wentz has thrown six interceptions through three games, while
only throwing three touchdowns. He has been dealt a tough hand, as the Eagles have major
injury problems at the wide receiver position.
Alshon Jeffery has yet to play a game this season. John Hightower and DeSean Jackson were
both held out of practice on Friday and are listed as ‘questionable’ for this one. J.J. Arcega-
Whiteside is also ‘questionable,’ but he did “get some work” in practice on Friday.
The offensive line is also struggling with injuries. Lane Johnson and Jason Peters are both listed
San Francisco was able to get past its injury problems last week against the Giants in what was a
blowout win as a 4.5-point favorite. Starting quarterback Jimmy Garoppolo was held out with an
ankle injury, but he “still has a chance” to play this week. However, his absence at Friday’s
practice probably spells another week off.
The 49ers have some key defensive injuries. Defensive end Dee Ford was place on the injured
reserve with a neck injury, while cornerbacks Emmanuel Moseley, Ahkello Witherspoon and
K’Waun Williams are all listed as ‘questionable.’
Tight end Jordan Reed is out for six-to-eight weeks with a left knee sprain. Running back
Raheem Mostert did not practice on Thursday and is also ‘questionable.’ George Kittle is
expected to return after misses two games with a knee injury.
Injuries aside, San Francisco did pick up the 36-9 win in Week 3 without a bunch of starters.
Nick Mullens made the start at quarterback, completing 25 of 36 passes for 343 yards and a
Rookie Brandon Aiyuk had a nice day, rushing for 31 yards and a touchdown on three carries,
while also catching five passes for 70 yards. Kendrick Bourne added four receptions for 63
Philadelphia is coming off the first tie of the 2020 NFL season. The Eagles and Bengals both
failed to score during overtime, working their way to a 23-23 final. Wentz went 29 of 47 through
the air for 225 yards. He threw one touchdown and two interceptions.
Miles Sanders led the rushing attack with 18 carries for 95 yards. Wentz scrambled for 65 yards
and a touchdown on nine attempts. Wide receiver Greg Ward Jr. was the top target in the passing
game, catching eight passes for 72 yards and a touchdown. Tight end Zach Ertz added seven
receptions for 70 yards.
Philadelphia has covered the spread at a 7-1 clip in its last eight games against San Francisco,
winning six of the games outright. The Eagles are 5-0 ATS in their last five games at Levi’s
San Francisco is 5-2 ATS in its last seven games and has won eight of its last 11 home games.
The ‘over’ is 7-3 in the last 10 head-to-head meetings between these two teams.
The pick: Philadelphia +7
The injury situation for both teams makes this a tough one to call. However, Philadelphia will be
in desperation mode and this is a step up in competition for a San Francisco team that has faced
the Jets and Giants in its last two games. The Eagles have been solid against the 49ers in recent
years. Their defense is good enough to keep this game low-scoring, which makes a 7-point
spread even more valuable. As long as Wentz can avoid turnovers against a thin secondary, the
Eagles should be able to cover this number. Their defense, led by Fletcher Cox, can attack a San
Francisco offensive line that is missing key pieces.