49ers vs Colts Match Player Stats | Week 16 Monday 2025

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SF @ IND

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Todays Matchup Details

Week 16 San Francisco 49ers at Indianapolis Colts
Todays Game is on Monday, December 22nd
22/12/25 20:15:00 PM EST Kickoff

Positives for the San Francisco 49ers Game Today

The 8th-largest volume of plays in football have been called by the 49ers this year (a staggering 59.4 per game on average).

This game will be played in a dome—meaning no wind, higher pass volume, higher touchdown potential, and increased passing efficiency.

The Colts defense has been a bit of pass funnel this year, leading opposing quarterbacks to attempt the 2nd-most passes in the NFL (38.9 per game) this year.

With an exceptional 69.1% Adjusted Completion% (86th percentile) this year, Brock Purdy ranks among the most on-target passers in the NFL.

With a stellar 8.04 adjusted yards-per-target (86th percentile) this year, Brock Purdy has been as one of the most effective quarterbacks in the NFL.

The Indianapolis Colts will be forced to start backup quarterback Philip Rivers in this week’s game, which generally means fewer pass attempts and more rushes.

This week’s line indicates a throwing game script for the Colts, who are -6-point underdogs.

The model projects the Indianapolis Colts as the 9th-most pass-heavy team on the slate this week with a 59.9% pass rate, accounting for their underlying traits and matchup dynamics.

Opposing offenses have averaged 35.9 pass attempts per game against the 49ers defense this year: 9th-most in the NFL.

Negatives with the Indianapolis Colts Game Today

With a 6-point advantage, the 49ers are favored in this week’s contest, implying more of an emphasis on running than their usual approach.

The projections expect this game to have the 2nd-fewest plays run on the slate this week at 126.2 plays, based on the tendencies of each team and game dynamics.

Brock Purdy has passed for quite a few less adjusted yards per game (191.0) this season than he did last season (258.0).

Given their underlying propensities and game dynamics, the Colts are expected by the model to run only 62.2 offensive plays in this contest: the 3rd-lowest number on the slate this week.

The 8th-lowest number of plays in the NFL have been called by the Indianapolis Colts this year (just 54.9 per game on average).

This year, the tough 49ers defense has conceded the 9th-least adjusted yards-per-target in football to the opposing side: a feeble 7.3 yards.

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